Drivers of Prurigo Nodularis

Drivers of Prurigo Nodularis

What’s driving PN?

While PN pathophysiology is not completely understood, a growing understanding of PN pathophysiology reveals that it is driven by neuroimmune dysfunction, which manifests as1,2

Circular graphic with diagonal lines, representing itch and scratch
Itch
inflammation
Inflammation
Circular graphic with rows of smaller circles within, representing skin cells
Altered epidermal differentiation
nodule
Fibrosis
image

Drivers of Prurigo Nodularis

Itch, inflammation, altered epidermal differentiation, and fibrosis are the 4 pillars of PN. The pathophysiology of PN involves interactions between the nervous system, immune system, and skin.1-5

 

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Cytokines in AD & PN
A female model with simulated prurigo nodularis reaches over her shoulder to scratch raised firm nodules on her back due to severe itch she suffers

Disease Burden of PN
A woman with simulated prurigo nodularis reaches down to scratch raised firm nodules on her lower leg due to severe itch she suffers

Diagnosing PN
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Resources
  1. Bağci IS, Ruzicka T. IL-31: a new key player in dermatology and beyond. J Allergy Clin Immunol. 2018;141(3):858-866. doi:10.1016/j.jaci.2017.10.045
  2. Williams KA, Roh YS, Brown I, et al. Pathophysiology, diagnosis, and pharmacological treatment of prurigo nodularis. Expert Rev Clin Pharmacol. 2021;14(1):67-77. doi:10.1080/17512433.2021.1852080
  3. Whang KA, Mahadevan V, Bakhshi PR, et al. Prevalence of prurigo nodularis in the United States. J Allergy Clin Immunol Pract. 2020;8(9):3240-3241.doi:10.1016/j.jaip.2020.05.051

References

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