Disease Burden of Prurigo Nodularis
The burden of PN is oppressive
PN severely impacts many aspects of patients’ lives—it leaves some suffering with intractable itch, disfiguring nodules, debilitating sleep disturbance, and impacts on their psychological well-being.1
A study has shown that patients with PN experience a higher burden of disease than patients with several other chronic pruritic skin diseases.
The study also showed that itch in PN was more severe than that of the other skin diseases.2
49%
of adults with PN reported that itch was the most burdensome symptom of their skin disease.3,*
21%
of adults with PN reported that the visibility of nodules was the most burdensome aspect of their skin disease.3,*
30%
of adults with PN reported that sleep improvement was among their top 3 treatment goals.4,†
15%
of adults with PN reported having suicidal thoughts that related to their skin disease.5,‡
Footnotes
*Results were based on a 2020 multicentre, cross-sectional European study of 509 adults with PN. This prospective, questionnaire-based study assessed the clinical profile of PN, as well as its associated burdens.3
†Results were based on a 2020 multicentre, cross-sectional European study of 509 patients with PN. This prospective, questionnaire-based study assessed patient perception of therapeutic goals, as well as previously used therapies, overall satisfaction with therapy, the efficacy of available therapeutic regimens, and out-of-pocket costs.4
‡Results were based on a 2019 multicentre European study of 3635 general dermatology outpatients and 1359 healthy controls. Twenty-seven of these general dermatology patients met study criteria for PN and were assessed for psychological burden of disease.5
- Janmohamed SR, Gwillim EC, Yousaf M, Patel KR, Silverberg JI. The impact of prurigo nodularis on quality of life: a systematic review and meta-analysis. Arch Dermatol Res. 2021;313(8):669-677. doi:10.1007/s00403-020-02148-0
- Steinke S, Zeidler C, Riepe C, et al. Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: results of the European Academy of Dermatology and Venereology Network on Assessment of Severity and Burden of Pruritus (PruNet) cross-sectional trial. J Am Acad. Dermatol. 2018;79(3):457-463.e5. doi:10.1016/j.jaad.2018.04.044
- Pereira MP, Hoffmann V, Weisshaar E, et al. Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study. J Eur Acad Dermatol Venereol. 2020;34(10):2373-2383. doi:10.1111/jdv.16309
- Pereira MP, Zeidler C, Wallengren J, et al. Chronic nodular prurigo: a European cross-sectional study of patient perspectives on therapeutic goals and satisfaction. Acta Derm Venereol. 2021;101(2):adv00403. doi:10.2340/00015555-3726
- Brenaut E, Halvorsen JA, Dalgard FJ, et al. The self-assessed psychological comorbidities of prurigo in European patients: a multicentre study in 13 countries. J Eur Acad Dermatol Venereol. 2019;33(1):157-162. doi:10.1111/jdv.15145
References